| Variant | Mutation | Mut count | Country count | Continent count | First date |
|---|---|---|---|---|---|
| PQ.10.1.3 | ORF1a:T2648I | 12 | 2 | 2 | 2025-12-07 |
| RE.2.2.4 | ORF1b:P1161S | 7 | 4 | 2 | 2025-12-08 |
| XFG.6.3 | ORF1a:G2265S | 4 | 2 | 2 | 2025-12-08 |
| XFG.6.3 | ORF1a:N2405S | 4 | 2 | 2 | 2025-12-08 |
| PQ.39.1 | ORF1b:I2147M | 11 | 5 | 1 | 2025-12-09 |
| RE.1.1 | S:P1162L | 4 | 2 | 2 | 2025-12-09 |
| PQ.2.1.5 | ORF1a:L3606F | 8 | 2 | 2 | 2025-12-10 |
| RE.2.2.4 | S:-211A | 16 | 4 | 2 | 2025-12-10 |
| RE.2.2.4 | S:I212S | 16 | 4 | 2 | 2025-12-10 |
| RE.2.2.4 | S:R214T | 17 | 5 | 2 | 2025-12-10 |
| RE.2.2.4 | S:V213D | 16 | 4 | 2 | 2025-12-10 |
| QY.2 | S:S680F | 8 | 3 | 2 | 2025-12-11 |
| XFG.5.1.7 | ORF1a:E269K | 7 | 7 | 3 | 2025-12-12 |
| PQ.2.1 | ORF1a:I842T | 4 | 2 | 2 | 2025-12-13 |
| XFY.1 | S:I212L | 7 | 2 | 2 | 2025-12-13 |
| XFY | ORF1a:P4223S | 6 | 2 | 2 | 2025-12-14 |
| NB.1.8.1 | ORF1b:V1528I | 5 | 2 | 2 | 2025-12-15 |
| RC.1 | ORF1a:I1206T | 4 | 2 | 2 | 2025-12-15 |
| XFG.1.1.2 | ORF1a:T265I | 59 | 2 | 2 | 2025-12-15 |
| XFG.17.2.1 | ORF1a:L580F | 4 | 3 | 2 | 2025-12-15 |
| XFG.5.1.7 | ORF8:S67A | 4 | 3 | 2 | 2025-12-15 |
| XGA.1 | N:T141I | 9 | 4 | 2 | 2025-12-15 |
| XFG.5.1.7 | ORF3a:I123T | 6 | 4 | 2 | 2025-12-16 |
| PQ.41 | ORF1a:I453T | 5 | 9 | 2 | 2025-12-17 |
| QF.7 | ORF1b:P1821S | 51 | 5 | 3 | 2025-12-17 |
| RE.1.1 | ORF8:-120F | 20 | 3 | 2 | 2025-12-17 |
| XGA.2 | ORF1a:D2299E | 6 | 6 | 2 | 2025-12-17 |
| RE.2.1.1 | S:-211A | 13 | 4 | 1 | 2025-12-18 |
| RE.2.1.1 | S:I212S | 13 | 4 | 1 | 2025-12-18 |
| RE.2.1.1 | S:R214T | 13 | 4 | 1 | 2025-12-18 |
| RE.2.1.1 | S:V213D | 13 | 4 | 1 | 2025-12-18 |
| XFG.5.1.7 | ORF1a:T770I | 5 | 2 | 2 | 2025-12-18 |
| NB.1.8.1 | S:G1085R | 4 | 4 | 2 | 2025-12-19 |
| NB.1.8.1 | S:T941S | 4 | 4 | 2 | 2025-12-19 |
| PQ.2.1 | ORF1a:A3143V | 9 | 5 | 3 | 2025-12-20 |
| RE.1.1.1 | ORF8:-120F | 24 | 5 | 2 | 2025-12-21 |
| RE.1.1.1 | S:-211A | 13 | 4 | 2 | 2025-12-21 |
| RE.1.1.1 | S:I212S | 13 | 4 | 2 | 2025-12-21 |
| RE.1.1.1 | S:R214T | 13 | 4 | 2 | 2025-12-21 |
| RE.1.1.1 | S:V213D | 13 | 4 | 2 | 2025-12-21 |
| PQ.2.1.7 | N:T362I | 6 | 3 | 2 | 2025-12-22 |
| PQ.2.1.7 | S:E156V | 6 | 3 | 2 | 2025-12-22 |
| XFG.6.4 | N:S37P | 4 | 2 | 2 | 2025-12-22 |
| PQ.43.1.1 | ORF3a:S40P | 20 | 3 | 2 | 2025-12-24 |
| PQ.17.2.1 | ORF7a:I110L | 8 | 3 | 2 | 2025-12-25 |
| XFG.17.2.1 | ORF1b:S763L | 4 | 2 | 2 | 2025-12-27 |
| XFG.17.2.1 | ORF3a:S40L | 4 | 2 | 2 | 2025-12-27 |
| QF.2.1 | ORF1a:E4388K | 5 | 2 | 2 | 2025-12-29 |
| RP.1 | S:G1146D | 5 | 2 | 2 | 2025-12-29 |
| XFG.5.1.7 | ORF1b:A1744D | 4 | 2 | 2 | 2026-01-03 |
| QF.2.1 | ORF1b:V2406A | 4 | 3 | 2 | 2026-01-04 |
| PQ.17.5 | ORF1a:F1867L | 4 | 5 | 2 | 2026-01-05 |
| PQ.17.5 | S:S446T | 4 | 5 | 2 | 2026-01-05 |
| PQ.2.5.3 | S:R681H | 4 | 2 | 2 | 2026-01-05 |
| PY.1.1.1 | ORF1a:T1638N | 4 | 2 | 2 | 2026-01-05 |
| PQ.2.1.3 | ORF1a:H1108Y | 6 | 2 | 2 | 2026-01-07 |
| RF.5 | N:T362I | 4 | 4 | 2 | 2026-01-09 |